HERMA has developed a modular tamper-evident labeling machine for the tamper-proof sealing of pharmaceutical packaging. The system seals folding boxes with different kinds of sealing labels. Thanks to this first-opening guarantee, packages that have been opened can no longer be resealed without detection, so that EU directive 2011/62/EU can be fulfilled. The system masters another challenge during the labeling process. Both equilateral ("airplane tuck-in") as well as opposing ("reverse tuck-in") stick claps can be handled, as well as hot glue claps can be additionally protected. In order to provide the required versatility, HERMA uses different format sets that can be easily and quickly changed by the user. In addition to sealing labels, the machine can also apply vignette or Bollini labels.